CHST1

CHST1
Tanımlayıcılar
Başka adlar	CHST1
Dış kimlikler	OMIM: 603797 MGI: 1924219 HomoloGene: 2711 GeneCards: CHST1
Gen yerleşimi (İnsan) Krom. 11. Kromozom (insan) Bant 11p11.2 Başlangıç 45,647,689 bç Bitiş 45,665,622 bç
RNA ekspresyonu deseni Daha çok ekspresyon verisi başvurusu
Gen ontolojisi Moleküler işlevi • transferase activity • sulfotransferase activity • N-acetylglucosamine 6-O-sulfotransferase activity • keratan sulfotransferase activity Hücresel bileşeni • Golgi membrane • Golgi aygıtı • membrane • integral component of membrane • trans-Golgi network Biyolojik süreci • sulfur compound metabolic process • galactose metabolic process • inflammatory response • keratan sulfate biosynthetic process • polysaccharide metabolic process • keratan sulfate metabolic process • carbohydrate metabolic process • N-acetylglucosamine metabolic process Kaynaklar:Amigo / QuickGO
Ortologlar
Türler	İnsan	Fare
Entrez	8534	76969
Ensembl	ENSG00000175264	ENSMUSG00000027221
UniProt	O43916	Q9EQC0
RefSeq (mRNA)	NM_003654	NM_023850 NM_001356552 NM_001356553
RefSeq (protein)	NP_003645	NP_076339 NP_001343481 NP_001343482
Yerleşim (UCSC)	Krom. 11: 45.65 – 45.67 Mb	n/a
PubMed araması
Vikiveri
İnsan'ı Gör/Düzenle Fare'yi Gör/Düzenle

Karbonhidrat sülfotransferaz 1, insanlarda 11. kromozomun kısa kolunda bulunan CHST1 geni tarafından kodlanan bir proteindir. Proteinin polipeptit zincirinin uzunluğu 411 amino asittir ve molekül ağırlığı 46715'tir.

Proteinin kodlandığı gen, işlev bakımından transferazlara aittir. Enflamatuvar yanıt, karbonhidrat metabolizması gibi biyolojik süreçlerde etkinlik gösterir. Protein, golgi aygıtının zarında yerleşir.

Ayrıca bakınız

• 11. kromozom

Dış bağlantılar

• İnsan CHST130 Aralık 2019 tarihinde Wayback Machine sitesinde arşivlendi. genomunun yerleşimi ve CHST1 geninin ayrıntıları UCSC Genom Tarayıcısı'nda.

Konuyla ilgili yayınlar

• Mazany K.D., Peng T., Watson C.E., Tabas I., Williams K.J. (1998). "Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization". Biochim. Biophys. Acta. Cilt 1407. s. 92 — 97. KB1 bakım: Birden fazla ad: yazar listesi (link) PMID 9639683 DOI:10.1016/S0925-4439(98)00028-3
• Li X., Tedder T.F. (1999). "CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization". Genomics. Cilt 55. s. 345 — 347.  PMID 10049591 DOI:10.1006/geno.1998.5653
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. Cilt 14. 2004. s. 2121 — 2127.  PMID 15489334 DOI:10.1101/gr.2596504
• Torii T., Fukuta M., Habuchi O. (2000). "Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase". Glycobiology. Cilt 10. s. 203 — 211. KB1 bakım: Birden fazla ad: yazar listesi (link) PMID 10642612 DOI:10.1093/glycob/10.2.203
• Williams KJ (1997). "Atherosclerosis: cell biology and lipoproteins". Curr. Opin. Lipidol. 7 (6). ss. U202-8. doi:10.1097/00041433-199612000-00016. PMID 9117134. 
• Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein". J. Virol. 66 (12). ss. 6953-9. PMC 240329 $2. PMID 1433500. 
• Shilatifard A, Merkle RK, Helland DE (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine". J. Virol. 67 (2). ss. 943-52. PMC 237448 $2. PMID 8419650. 
• Li X, Tedder TF (1999). "CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization". Genomics. 55 (3). ss. 345-7. doi:10.1006/geno.1998.5653. PMID 10049591. 
• Bistrup A, Bhakta S, Lee JK (1999). "Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin". J. Cell Biol. 145 (4). ss. 899-910. doi:10.1083/jcb.145.4.899. PMC 2133194 $2. PMID 10330415. 
• Tu L, Murphy PG, Li X, Tedder TF (1999). "L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1". J. Immunol. 163 (9). ss. 5070-8. PMID 10528213. 
• Torii T, Fukuta M, Habuchi O (2000). "Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase". Glycobiology. 10 (2). ss. 203-11. doi:10.1093/glycob/10.2.203. PMID 10642612. 
• Li X, Tu L, Murphy PG (2001). "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin". J. Leukoc. Biol. 69 (4). ss. 565-74. PMID 11310842. 
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15.000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26). ss. 16899-903. doi:10.1073/pnas.242603899. PMC 139241 $2. PMID 12477932. 
• Yamada T, Ohtake S, Sato M, Habuchi O (2005). "Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues". Biochem. J. 384 (Pt 3). ss. 567-75. doi:10.1042/BJ20040965. PMC 1134142 $2. PMID 15324304. 
• Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B). ss. 2121-7. doi:10.1101/gr.2596504. PMC 528928 $2. PMID 15489334. 
• Rual JF, Venkatesan K, Hao T (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). ss. 1173-8. doi:10.1038/nature04209. PMID 16189514. 
• Liu J, Chau CH, Liu H (2006). "Upregulation of chondroitin 6-sulphotransferase-1 facilitates Schwann cell migration during axonal growth". J. Cell Sci. 119 (Pt 5). ss. 933-42. doi:10.1242/jcs.02796. PMID 16495484. 
• Kitayama K, Hayashida Y, Nishida K, Akama TO (2007). "Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans". J. Biol. Chem. 282 (41). ss. 30085-96. doi:10.1074/jbc.M703695200. PMID 17690104.